Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis

Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response relationship has been observed. We performed a systematic review of studies that investigate the association between the degree of cannabis consumption and psychosis and a meta-analysis to quantify the magnitude of effect. Published studies were identified through search of electronic databases, supplemented by manual searches of bibliographies. Studies were considered if they provided data on cannabis consumption prior to the onset of psychosis using a dose criterion (frequency/amount used) and reported psychosis-related outcomes. We performed random effects meta-analysis of individual data points generated with a…

• SA
  Systematics Association
• MR
  Medical Research Council

  Awards: MR/M008436/1, MR/K004867/1, MR/K013807/1