reviewNutrientsJan 20, 2016GOLD OA

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

TATrisha A. JenkinsJNJason NguyenKPKate PolglazePBPaul Bertrand

RMIT University · UNSW Sydney

PubMed
Indexed incrossrefdoajpubmed

Abstract

The serotonergic system forms a diffuse network within the central nervous system and plays a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels, acutely or chronically, by depletion or supplementation, is an experimental procedure for modifying peripheral and central serotonin levels. These studies have allowed us to establish the role of serotonin in higher order brain function in both preclinical and clinical situations and have precipitated the finding that low brain serotonin levels are associated with poor memory and depressed mood. The gut-brain axis is a bi-directional system between the brain and gastrointestinal tract, linking emotional and cognitive centres…

Citation impact

877
total citations
FWCI
28.65
Percentile
100%
References
138
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Serotonergic
  • Serotonin
  • Neuroscience
  • Mood
  • Central nervous system
  • Gut–brain axis
  • Cognition
  • Psychology
No related works found for this paper.

Funding