Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment
Gachon University · Kyungpook National University
Abstract
Distinct tumor microenvironment forms in each progression step of cancer and has diverse capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now known that immune cells can be activated to favor tumor growth and progression, most probably influenced by the tumor microenvironment. Tumor-associated macrophages and tumor-associated neutrophils can exert protumoral functions, enhancing tumor cell invasion and metastasis, angiogenesis, and extracellular matrix remodeling, while inhibiting the antitumoral immune surveillance. Considering that neutrophils in inflammatory environments recruit macrophages and that recruited macrophages affect neutrophil functions, there may be various…
Citation impact
- FWCI
- 19.77
- Percentile
- 100%
- References
- 109
Authors
2Topics & keywords
- Tumor microenvironment
- Tumor progression
- Immune system
- Angiogenesis
- Cancer research
- Macrophage
- Extracellular matrix
- Carcinogenesis
- Good health and well-being
Funding
- NRNational Research Foundation
- GUGachon UniversityAwards: HI15C0001, 2014R1A2A1A11049526, 2012-M072, NRF-2014R1A1A1004682
- MOMinistry of Science, ICT and Future PlanningAwards: 2012-M072, HI15C0001, NRF-2014R1A1A1004682, 2014R1A2A1A11049526
- KHKorea Health Industry Development InstituteAwards: NRF-2014R1A1A1004682, 2014R1A2A1A11049526, 2012-M072, HI15C0001
- NRNational Research Foundation of KoreaAwards: NRF-2014R1A1A1004682, HI15C0001, 2014R1A2A1A11049526, 2012-M072