Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
Washington University in St. Louis · Duke University · +13 more institutions
Abstract
Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age- and growth-discriminatory taxa from the microbiota of the former were able to invade that of…
Citation impact
- FWCI
- 65.32
- Percentile
- 100%
- References
- 42
Authors
20Topics & keywords
- Bacteria
- Gut bacteria
- Biology
- Gut flora
- Environmental health
- Microbiology
- Medicine
- Immunology
- Zero hunger
Funding
- USUnited States Agency for International DevelopmentAwards: AID-OAA-A-12-00005, FHI 360
- BABill and Melinda Gates FoundationAwards: 252075, FHI 360
- WUWashington University in St. Louis
- F3FHI 360
- AOAcademy of FinlandAward: 252075
- RSRussian Science FoundationAward: 14-14-00289
- TTaysAward: 9M004
- NINational Institutes of HealthAwards: T32 GM007067, T32 AI007172, GM007067, P30 AR057235, AI007172, AR057235
- MRMusculoskeletal Research Center, Washington University in St. LouisAward: P30 AR057235