Cells release subpopulations of exosomes with distinct molecular and biological properties

Cells release nano-sized membrane vesicles that are involved in intercellular communication by transferring biological information between cells. It is generally accepted that cells release at least three types of extracellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes. While a wide range of putative biological functions have been attributed to exosomes, they are assumed to represent a homogenous population of EVs. We hypothesized the existence of subpopulations of exosomes with defined molecular compositions and biological properties. Density gradient centrifugation of isolated exosomes revealed the presence of two distinct subpopulations, differing in biophysical properties and their…

• ET
  Eesti Teadusagentuur

  Award: PUT618
• C
  Cancerfonden
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek
• SS
  Svenska Sällskapet för Medicinsk Forskning
• KI
  Karolinska Institutet
• V
  Vetenskapsrådet