Re-evaluation of G-quadruplex propensity with G4Hunter

Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been obtained in seminal studies performed in a variety of organisms. Four-stranded G-quadruplex DNA structures are promising drug targets as these non-canonical structures appear to be involved in a number of key biological processes. Given the growing interest for G4, accurate tools to predict G-quadruplex propensity of a given DNA or RNA sequence are needed. Several algorithms such as Quadparser predict quadruplex forming propensity. However, a number of studies have established that sequences that are not detected by these tools do form G4 structures (false negatives) and that other sequences predicted to form G4 structures…

• AN
  Agence Nationale de la Recherche

  Awards: ANR-12-IS07-0001, ANR-10-NANO-04-03, ANR-12-BSV8-0008-01, ANR-12, ANR-10, ANR-12-BSV8-0008
• IN
  Institut National de la Santé et de la Recherche Médicale
• FA
  Fondation ARC pour la Recherche sur le Cancer
• UD
  Université de Toulouse