Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment
Université Paris Cité · Centre National de la Recherche Scientifique · +2 more institutions
Abstract
The pursuit of innovative, multifunctional, more efficient, and safer treatments is a major challenge in preclinical nanoparticle-mediated thermotherapeutic research. Here, we report that iron oxide nanoparticles have the dual capacity to act as both magnetic and photothermal agents. We further explore every key aspect of this magnetophotothermal approach, choosing iron oxide nanocubes for their high efficiency for the magnetic hyperthermia modality itself. In aqueous suspension, the nanocubes' exposure to both: an alternating magnetic field and near-infrared laser irradiation (808 nm), defined as the DUAL-mode, amplifies the heating effect 2- to 5-fold by comparison with magnetic stimulation alone, yielding…
Citation impact
- FWCI
- 50.50
- Percentile
- 100%
- References
- 56
Authors
6- AEAna EspinosaCorresponding
Université Paris Cité, Centre National de la Recherche Scientifique, Laboratoire Matière et Systèmes Complexes
- RDRiccardo Di Corato
Laboratoire Matière et Systèmes Complexes, Centre National de la Recherche Scientifique, Université Paris Cité
- JKJelena Kolosnjaj‐Tabi
Laboratoire Matière et Systèmes Complexes, Centre National de la Recherche Scientifique, Université Paris Cité
- PFPatrice Flaud
Université Paris Cité, Laboratoire Matière et Systèmes Complexes, Centre National de la Recherche Scientifique
- TPTeresa Pellegrino
Italian Institute of Technology
Topics & keywords
- Photothermal therapy
- Hyperthermia
- Materials science
- Magnetic hyperthermia
- Iron oxide nanoparticles
- Heat generation
- Dual mode
- Magnetic nanoparticles