Endoplasmic Reticulum Stress and Associated ROS
Jeonbuk National University · Wonkwang University
Abstract
The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins, after which they are directed either toward other organelles or to degradation, respectively. The ER redox environment dictates the fate of entering proteins, and the level of redox signaling mediators modulates the level of reactive oxygen species (ROS). Accumulating evidence suggests the interrelation of ER stress and ROS with redox signaling mediators such as protein disulfide isomerase (PDI)-endoplasmic reticulum oxidoreductin (ERO)-1, glutathione (GSH)/glutathione disuphide (GSSG), NADPH oxidase 4 (Nox4), NADPH-P450 reductase…
Citation impact
- FWCI
- 38.02
- Percentile
- 100%
- References
- 180
Authors
4Topics & keywords
- Endoplasmic reticulum
- Unfolded protein response
- Protein disulfide-isomerase
- Cell biology
- Oxidative stress
- Glutathione
- Reactive oxygen species
- NOX4