Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease
University of California, San Francisco · University Memory and Aging Center · +5 more institutions
Abstract
SEE SARAZIN ET AL DOI101093/BRAIN/AWW041 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The advent of the positron emission tomography tracer (18)F-AV1451 provides the unique opportunity to visualize the regional distribution of tau pathology in the living human brain. In this study, we tested the hypothesis that tau pathology is closely linked to symptomatology and patterns of glucose hypometabolism in Alzheimer's disease, in contrast to the more diffuse distribution of amyloid-β pathology. We included 20 patients meeting criteria for probable Alzheimer's disease dementia or mild cognitive impairment due to Alzheimer's disease, presenting with a variety of clinical phenotypes, and 15 amyloid-β-negative…
Citation impact
- FWCI
- 80.40
- Percentile
- 100%
- References
- 96
Authors
20- RORik OssenkoppeleCorresponding
University of California, San Francisco, University Memory and Aging Center, Amsterdam Neuroscience, University of California, Berkeley
- DRDaniel R. Schonhaut
University of California, San Francisco, University Memory and Aging Center, University of California, Berkeley
- MSMichael Schöll
University of Gothenburg, University of California, Berkeley
- SNSamuel N. Lockhart
University of California, Berkeley
- NANagehan Ayakta
University of California, San Francisco, University Memory and Aging Center, University of California, Berkeley
Topics & keywords
- Posterior cortical atrophy
- Primary progressive aphasia
- Positron emission tomography
- Dementia
- Pathology
- Alzheimer's disease
- Psychology
- Disease