Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Université de Montpellier · Cellular Therapeutics (United Kingdom) · +3 more institutions
Abstract
UNLABELLED: "Liquid biopsy" focusing on the analysis of circulating tumor cells (CTC) and circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received enormous attention because of its obvious clinical implications for personalized medicine. Analyses of CTCs and ctDNA have paved new diagnostic avenues and are, to date, the cornerstones of liquid biopsy diagnostics. The present review focuses on key areas of clinical applications of CTCs and ctDNA, including detection of cancer, prediction of prognosis in patients with curable disease, monitoring systemic therapies, and stratification of patients based on the detection of therapeutic targets or resistance mechanisms. SIGNIFICANCE:…
Citation impact
- FWCI
- 71.33
- Percentile
- 100%
- References
- 122
Authors
2Topics & keywords
- Liquid biopsy
- Circulating tumor cell
- Circulating tumor DNA
- DNA
- Cancer research
- Tumor cells
- Computational biology
- Pathology
- Good health and well-being