STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data
University of Zurich · SIB Swiss Institute of Bioinformatics · +5 more institutions
Abstract
Interactions between proteins and small molecules are an integral part of biological processes in living organisms. Information on these interactions is dispersed over many databases, texts and prediction methods, which makes it difficult to get a comprehensive overview of the available evidence. To address this, we have developed STITCH ('Search Tool for Interacting Chemicals') that integrates these disparate data sources for 430 000 chemicals into a single, easy-to-use resource. In addition to the increased scope of the database, we have implemented a new network view that gives the user the ability to view binding affinities of chemicals in the interaction network. This enables the user to get a quick…
Citation impact
- FWCI
- 63.96
- Percentile
- 100%
- References
- 42
Authors
6- DSDamian Szklarczyk
University of Zurich, SIB Swiss Institute of Bioinformatics
- ASAlberto Santos
Novo Nordisk Foundation, University of Copenhagen
- CVChristian von Mering
University of Zurich, SIB Swiss Institute of Bioinformatics
- LJLars Juhl Jensen
Novo Nordisk Foundation, University of Copenhagen
- PBPeer Bork
Max Delbrück Center, European Molecular Biology Laboratory
Topics & keywords
- Biology
- Scope (computer science)
- Interface (matter)
- Computational biology
- Organism
- Biological network
- Resource (disambiguation)
- Computer science