MYC regulates the antitumor immune response through CD47 and PD-L1

Casey, Stephanie C.; Tong, Ling; Li, Yulin; Do, Rachel; Walz, Susanne; Fitzgerald, Kelly N.; Gouw, Arvin M.; Baylot, Virginie; Gütgemann, Ines; Eilers, Martin; Felsher, Dean W.

doi:10.1126/science.aac9935

articleScienceMar 10, 2016GREEN OA

MYC regulates the antitumor immune response through CD47 and PD-L1

SCStephanie C. Casey LTLing Tong YLYulin Li RDRachel Do SWSusanne Walz

Stanford University · University of Würzburg · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The MYC oncogene codes for a transcription factor that is overexpressed in many human cancers. Here we show that MYC regulates the expression of two immune checkpoint proteins on the tumor cell surface: the innate immune regulator CD47 (cluster of differentiation 47) and the adaptive immune checkpoint PD-L1 (programmed death-ligand 1). Suppression of MYC in mouse tumors and human tumor cells caused a reduction in the levels of CD47 and PD-L1 messenger RNA and protein. MYC was found to bind directly to the promoters of the Cd47 and Pd-l1 genes. MYC inactivation in mouse tumors down-regulated CD47 and PD-L1 expression and enhanced the antitumor immune response. In contrast, when MYC was inactivated in tumors…

Citation impact

1,375

total citations

FWCI: 54.80
Percentile: 100%
References: 54

Citations per year

Authors

11

Topics & keywords

Topics

Keywords

Immune system
Biology
Oncogene
CD47
Immune checkpoint
Cancer research
Transcription factor
Carcinogenesis

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.