Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers
State Key Laboratory of Digital Medical Engineering · Southeast University · +3 more institutions
Abstract
The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters. To study the ROS scavenging ability of PBNPs, a series of in vitro ROS-generating…
Citation impact
- FWCI
- 21.95
- Percentile
- 100%
- References
- 40
Authors
8- WZWei ZhangCorresponding
State Key Laboratory of Digital Medical Engineering, Southeast University
- SHSunling Hu
Southeast University, State Key Laboratory of Digital Medical Engineering
- JYJun‐Jie Yin
Center for Food Safety and Applied Nutrition, United States Food and Drug Administration
- WHWeiwei He
United States Food and Drug Administration, Center for Food Safety and Applied Nutrition
- WLWei Lu
Southeast University, Nanjing Medical University
Topics & keywords
- Chemistry
- Reactive oxygen species
- Prussian blue
- Catalase
- Superoxide dismutase
- Radical
- Hydroxyl radical
- Biophysics
Funding
- NNNational Natural Science Foundation of ChinaAwards: 31170959, 81571806
- MOMinistry of Science and Technology of the People's Republic of ChinaAwards: 2013CB733800, 2011CB933503
- GOGovernment of Jiangsu ProvinceAward: BL2013029
- UFU.S. Food and Drug Administration
- BRBasic Research Program of Jiangsu ProvinceAward: BK2011036