Early and protective microglial activation in Alzheimer’s disease: a prospective study using 18 F-DPA-714 PET imaging
Centre National de la Recherche Scientifique · Inserm · +18 more institutions
Abstract
While emerging evidence suggests that neuroinflammation plays a crucial role in Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a matter of debate. We aimed to study microglial activation in early Alzheimer's disease and its impact on clinical progression using a second-generation 18-kDa translocator protein positron emission tomography radiotracer together with amyloid imaging using Pittsburgh compound B positron emission tomography. We enrolled 96 subjects, 64 patients with Alzheimer's disease and 32 controls, from the IMABio3 study, who had both (11)C-Pittsburgh compound B and (18)F-DPA-714 positron emission tomography imaging. Patients with Alzheimer's disease were…
Citation impact
- FWCI
- 29.64
- Percentile
- 100%
- References
- 44
Authors
16- LHLorraine HamelinCorresponding
Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Institut d'Imagerie Biomédicale, Sorbonne Paris Cité, Centre Hospitalier Sainte-Anne, CEA Paris-Saclay
- JLJulien Lagarde
Inserm, Université Paris Cité, Sorbonne Paris Cité, Centre Hospitalier Sainte-Anne
- GDGuillaume Dorothée
Inserm, Sorbonne Université, Hôpital Saint-Antoine, Centre de Recherche Saint-Antoine
- CLClaire Leroy
Centre National de la Recherche Scientifique, Inserm, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, CEA Paris-Saclay
- MLM. Labit
Cognitive Neuroimaging Lab
Topics & keywords
- Pittsburgh compound B
- Translocator protein
- Positron emission tomography
- Dementia
- Alzheimer's disease
- Amyloid (mycology)
- Medicine
- Microglia
- Good health and well-being