Gut microbiota, obesity and diabetes
Teagasc - The Irish Agriculture and Food Development Authority · University College Cork · +1 more institution
Abstract
The central role of the intestinal microbiota in the progression and, equally, prevention of metabolic dysfunction is becoming abundantly apparent. The symbiotic relationship between intestinal microbiota and host ensures appropriate development of the metabolic system in humans. However, disturbances in composition and, in turn, functionality of the intestinal microbiota can disrupt gut barrier function, a trip switch for metabolic endotoxemia. This low-grade chronic inflammation, brought about by the influx of inflammatory bacterial fragments into circulation through a malfunctioning gut barrier, has considerable knock-on effects for host adiposity and insulin resistance. Conversely, recent evidence suggests…
Citation impact
- FWCI
- 16.54
- Percentile
- 100%
- References
- 237
Authors
7- EPElaine Patterson
Teagasc - The Irish Agriculture and Food Development Authority, University College Cork, APC Microbiome Institute
- PMPaul M. Ryan
Teagasc - The Irish Agriculture and Food Development Authority, University College Cork
- JFJohn F. Cryan
University College Cork, APC Microbiome Institute
- TGTimothy G. Dinan
University College Cork, APC Microbiome Institute
- RPR. Paul Ross
University College Cork, APC Microbiome Institute
Topics & keywords
- Gut flora
- Gastrointestinal tract
- Medicine
- Host (biology)
- Insulin resistance
- Inflammation
- Bioinformatics
- Diabetes mellitus
- Good health and well-being