Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Hong Kong Baptist University · Alberta Bone and Joint Health Institute · +13 more institutions
Abstract
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-3p associates with both elevated serum exosomal miR-214-3p and reduced bone formation in elderly women with fractures and in ovariectomized (OVX) mice. Osteoclast-specific miR-214-3p knock-in mice have elevated serum exosomal miR-214-3p and reduced bone formation that is rescued by osteoclast-targeted antagomir-214-3p treatment. We further demonstrate that osteoclast-derived exosomal miR-214-3p is…
Citation impact
- FWCI
- 24.37
- Percentile
- 100%
- References
- 48
Authors
34- DLDefang LiCorresponding
Hong Kong Baptist University, Alberta Bone and Joint Health Institute, Shenzhen Institute for Drug Control, Kunshan Industrial Technology Research Institute
- JLJin Liu
Hong Kong Baptist University, Alberta Bone and Joint Health Institute, Shenzhen Institute for Drug Control
- BGBaosheng Guo
Hong Kong Baptist University, Alberta Bone and Joint Health Institute, Shenzhen Institute for Drug Control, Kunshan Industrial Technology Research Institute
- CLChao Liang
Hong Kong Baptist University, Hunan University, Northwestern Polytechnical University, Alberta Bone and Joint Health Institute, Shenzhen Institute for Drug Control
- LDLei Dang
Hong Kong Baptist University, Alberta Bone and Joint Health Institute, Shenzhen Institute for Drug Control
Topics & keywords
- Osteoclast
- Osteoblast
- Ovariectomized rat
- Chemistry
- Cell biology
- Bone remodeling
- Internal medicine
- Endocrinology
- Good health and well-being