A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells
Hunan University · State Key Laboratory of Chemobiosensing and Chemometrics · +2 more institutions
Abstract
Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species to kill cancer cells. However, a high concentration of glutathione (GSH) is present in cancer cells and can consume reactive oxygen species. To address this problem, we report the development of a photosensitizer-MnO2 nanosystem for highly efficient PDT. In our design, MnO2 nanosheets adsorb photosensitizer chlorin e6 (Ce6), protect it from self-destruction upon light irradiation, and efficiently deliver it into cells. The nanosystem also inhibits extracellular singlet oxygen generation by Ce6, leading to fewer side effects. Once endocytosed, the MnO2 nanosheets are reduced by intracellular GSH. As a result,…
Citation impact
- FWCI
- 34.64
- Percentile
- 100%
- References
- 38
Authors
10- HFHuanhuan Fan
Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics
- GYGuobei Yan
Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics
- ZZZilong Zhao
Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics
- XHXiaoxiao Hu
Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics
- WZWenhan Zhang
Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics
Topics & keywords
- Photosensitizer
- Photodynamic therapy
- Manganese
- Glutathione
- Chemistry
- Cancer research
- Photochemistry
- Medicine
- Life in Land