Zika virus in the Americas: Early epidemiological and genetic findings

Faria, Nuno R.; Azevedo, Raimunda do Socorro da Silva; Kraemer, Moritz U. G.; Souza, Renato Pereira de; Cunha, Mariana Sequetin; Hill, Sarah C.; Thézé, Julien; Bonsall, Michael B.; Bowden, Thomas A.; Rissanen, Ilona; Rocco, Iray Maria; Nogueira, Juliana Silva; Maeda, Adriana Yurika; Vasami, Fernanda Giseli da Silva; Macedo, Fernando Luiz de Lima; Suzuki, Akemi; Rodrigues, Sueli Guerreiro; Cruz, Ana Cecília Ribeiro; Nunes, Bruno Tardeli; Medeiros, Daniele Barbosa de Almeida; Rodrigues, Daniela Sueli Guerreiro; Queiroz, Alice Louize Nunes; Silva, Eliana Vieira Pinto da; Henriques, Daniele Freitas; Rosa, Elisabeth Salbe Travassos da; Oliveira, Consuelo Silva de; Martins, Lívia Carício; Vasconcelos, Helena Baldez; Casseb, Lívia Medeiros Neves; Simith, Darlene de Brito; Messina, Jane P.; Abade, Leandro; Lourenço, José; Alcantara, Luiz Carlos Junior; Lima, Maricélia Maia de; Giovanetti, Marta; Hay, Simon I; Oliveira, Rodrigo Santos de; Lemos, Poliana da Silva; Oliveira, Layanna Freitas de; Lima, Clayton Pereira Silva de; Silva, Sandro Patroca da; Vasconcelos, Janaína Mota de; Franco, Luciano; Cardoso, Jedson Ferreira; Júnior, João Lídio da Silva Gonçalves Vianez; Mir, Daiana; Bello, Gonzalo; Delatorre, Edson; Khan, Kamran; Creatore, Marisa; Coelho, Giovanini Evelim; Oliveira, Wanderson Kleber de; Tesh, Robert B.; Pybus, Oliver G.; Nunes, Márcio Roberto Teixeira; Vasconcelos, Pedro Fernando da Costa

doi:10.1126/science.aaf5036

articleScienceMar 25, 2016GREEN OA

Zika virus in the Americas: Early epidemiological and genetic findings

NRNuno R. Faria RDRaimunda do Socorro da Silva Azevedo MUMoritz U. G. Kraemer RPRenato Pereira de Souza MSMariana Sequetin Cunha

University of Oxford · Instituto Evandro Chagas · +12 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015, and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. We performed next-generation sequencing to generate seven Brazilian ZIKV genomes sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Results of phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, which we estimated to have occurred between May and December 2013, more than 12 months before the detection of ZIKV in Brazil. The…

Citation impact

1,124

total citations

FWCI: 208.51
Percentile: 100%
References: 73

Citations per year

Authors

57

Topics & keywords

Topics

Keywords

Zika virus
Microcephaly
Outbreak
Epidemiology
Virology
Virus
Pregnancy
Biology

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.