Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody
University of North Carolina at Chapel Hill · North Carolina State University
Abstract
Despite recent advances in melanoma treatment through the use of anti-PD-1 (aPD1) immunotherapy, the efficacy of this method remains to be improved. Here we report an innovative self-degradable microneedle (MN) patch for the sustained delivery of aPD1 in a physiologically controllable manner. The microneedle is composed of biocompatible hyaluronic acid integrated with pH-sensitive dextran nanoparticles (NPs) that encapsulate aPD1 and glucose oxidase (GOx), which converts blood glucose to gluconic acid. The generation of acidic environment promotes the self-dissociation of NPs and subsequently results in the substantial release of aPD1. We find that a single administration of the MN patch induces robust immune…
Citation impact
- FWCI
- 31.14
- Percentile
- 100%
- References
- 41
Authors
5- CWChao WangCorresponding
University of North Carolina at Chapel Hill, North Carolina State University
- YYYanqi Ye
University of North Carolina at Chapel Hill, North Carolina State University
- GHGabrielle Hochu
North Carolina State University, University of North Carolina at Chapel Hill
- HSHasan Sadeghifar
North Carolina State University
- ZGZhen Gu
University of North Carolina at Chapel Hill, North Carolina State University
Topics & keywords
- Immunotherapy
- Hyaluronic acid
- Glucose oxidase
- Chemistry
- Dextran
- Cancer immunotherapy
- Melanoma
- Biocompatible material
- Good health and well-being