reviewCurrent NeuropharmacologyJan 20, 2016BRONZE OA

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

JZJi‐chun ZhangWYWei YaoKHKenji Hashimoto

Center for Forensic Mental Health, Chiba University

Indexed incrossref

Abstract

Depression is the most prevalent and among the most debilitating of psychiatric disorders. The precise neurobiology of this illness is unknown. Several lines of evidence suggest that peripheral and central inflammation plays a role in depressive symptoms, and that anti-inflammatory drugs can improve depressive symptoms in patients with inflammation-related depression. Signaling via brain-derived neurotrophic factor (BDNF) and its receptor, tropomycin receptor kinase B (TrkB) plays a key role in the pathophysiology of depression and in the therapeutic mechanisms of antidepressants. A recent paper showed that lipopolysaccharide (LPS)-induced inflammation gave rise to depression-like phenotype by altering…

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Topics & keywords

Topics
Keywords
  • Tropomyosin receptor kinase B
  • Neurotrophic factors
  • Nucleus accumbens
  • Brain-derived neurotrophic factor
  • Antidepressant
  • Medicine
  • Neuroscience
  • Prefrontal cortex
UN Sustainable Development Goals
  • Good health and well-being
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