Co(III)-Catalyzed C–H Activation/Formal S N -Type Reactions: Selective and Efficient Cyanation, Halogenation, and Allylation

The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal SN-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in Cp*Co(III)-catalyzed C-H activation for the first time.

• AV
  Alexander von Humboldt-Stiftung
• DF
  Deutsche Forschungsgemeinschaft
• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Award: 2013/14209-9
• ER
  European Research Council

  Award: 25936