Regulation of prefrontal cortex myelination by the microbiota
University College Cork · APC Microbiome Institute
Abstract
The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric disorders such as depression, schizophrenia and autism. In parallel, the role of the gut microbiota in contributing to these disorders is emerging. Germ-free (GF) animals, microbiota-deficient throughout life, have been instrumental in elucidating the role of the microbiota in many aspects of physiology, especially the role of the microbiota in anxiety-related behaviours, impaired social cognition and stress responsivity. Here we aim to further elucidate the mechanisms of the microbial influence by investigating changes in the homeostatic regulation of neuronal transcription of GF mice within the PFC using a genome-wide…
Citation impact
- FWCI
- 35.16
- Percentile
- 100%
- References
- 63
Authors
8- AEAlan E. HobanCorresponding
University College Cork, APC Microbiome Institute
- RMRoman M. Stilling
University College Cork, APC Microbiome Institute
- FJFeargal J. Ryan
University College Cork, APC Microbiome Institute
- FSFergus Shanahan
University College Cork, APC Microbiome Institute
- TGTimothy G. Dinan
University College Cork, APC Microbiome Institute
Topics & keywords
- Prefrontal cortex
- Neuroscience
- Transcriptome
- Gut–brain axis
- Biology
- Neuroplasticity
- Autism
- Gut flora
- Good health and well-being
Funding
- AAstraZeneca
- MJMead Johnson Nutrition
- NANational Alliance for Research on Schizophrenia and DepressionAward: 20771
- EIEnterprise Ireland
- SFScience Foundation IrelandAwards: 20771, 12/RC/2273, 12/RC/
- UOUniversity of Galway
- UCUniversity College Cork
- TCTrinity College Dublin
- IRIrish Research Council
- SServier
- HLH. Lundbeck A/S
- AMAPC Microbiome Institute