Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

SIGNIFICANCE: The endoplasmic reticulum (ER) is a specialized organelle for the folding and trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and extracellular stimuli. Alterations in the protein-folding environment cause accumulation of misfolded proteins in the ER that profoundly affect a variety of cellular signaling processes, including reduction-oxidation (redox) homeostasis, energy production, inflammation, differentiation, and apoptosis. The unfolded protein response (UPR) is a collection of adaptive signaling pathways that evolved to resolve protein misfolding and restore an efficient protein-folding environment. RECENT ADVANCES: Production of reactive oxygen…

• CA
  Crohn's and Colitis Foundation of America
• CA
  Crohn's and Colitis Foundation
• NI
  National Institutes of Health

  Awards: DK088227, DK042394, HL052173