Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)
Medical College of Wisconsin · Versiti Blood Center of Wisconsin · +1 more institution
Abstract
PURPOSE OF REVIEW: The purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, platelet/endothelial cell adhesion molecule-1 (PECAM-1), in endothelial cells, with special emphasis on its role in maintaining and restoring the vascular permeability barrier following disruption of the endothelial cell junction. RECENT FINDINGS: In addition to its role as an inhibitory receptor in circulating platelets and leukocytes, PECAM-1 is highly expressed at endothelial cell-cell junctions, where it functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability barrier following…
Citation impact
- FWCI
- 15.58
- Percentile
- 100%
- References
- 79
Authors
5- PLPanida Lertkiatmongkol
Medical College of Wisconsin, Versiti Blood Center of Wisconsin, Huazhong University of Science and Technology
- DLDanying Liao
Medical College of Wisconsin, Huazhong University of Science and Technology, Versiti Blood Center of Wisconsin
- HMHeng Mei
Huazhong University of Science and Technology, Versiti Blood Center of Wisconsin, Medical College of Wisconsin
- YHYu Hu
Medical College of Wisconsin, Versiti Blood Center of Wisconsin, Huazhong University of Science and Technology
- PJPeter J. NewmanCorresponding
Versiti Blood Center of Wisconsin
Topics & keywords
- Cell biology
- Endothelial stem cell
- Cell adhesion molecule
- Vascular permeability
- Cell adhesion
- CD31
- Soluble cell adhesion molecules
- Platelet