The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
Chinese University of Hong Kong · University of Hong Kong · +4 more institutions
Abstract
High heterogeneity of macrophage is associated with its functions in polarization to different functional phenotypes depending on environmental cues. Macrophages remain in balanced state in healthy subject and thus macrophage polarization may be crucial in determining the tissue fate. The two distinct populations, classically M1 and alternatively M2 activated, representing the opposing ends of the full activation spectrum, have been extensively studied for their associations with several disease progressions. Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the…
Citation impact
- FWCI
- 18.99
- Percentile
- 100%
- References
- 142
Authors
6- HTHor‐Yue Tan
Chinese University of Hong Kong, University of Hong Kong
- NWNing Wang
Chinese University of Hong Kong, University of Hong Kong
- SLSha Li
Chinese University of Hong Kong, University of Hong Kong
- MHMing Hong
Chinese University of Hong Kong, University of Hong Kong
- XWXuanbin Wang
Hubei University of Medicine, Hubei University of Chinese Medicine, Wuhan University, Renmin Hospital of Wuhan University
Topics & keywords
- Macrophage polarization
- Reactive oxygen species
- Macrophage
- Cell biology
- Phenotype
- Biology
- Inflammation
- Immunology
Funding
- GFGaia Family Trust, New ZealandAwards: 104002889, 200007477, 200007008, WDCM001, 200006276, 104003422
- UOUniversity of Hong KongAwards: 200006276, WDCM001, 104002889, 104003422, 200007008
- HUHubei University of MedicineAwards: 200007477, WDCM001, 200007008, 104002889, 200006276, 104003422
- HUHubei University
- HKHubei Key Laboratory of Wudang Local Chinese Medicine Research