Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Intercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-cell crosstalk that enables cells to convey packages of complex instructions to specific recipient cells. EVs transmit these instructions through their cargoes of multiple proteins, nucleic acids, and specialized lipids, which are derived from their cells of origin and allow for combinatorial effects upon recipient cells. This Review series brings together the recent progress in our understanding of EV signaling in physiological and pathophysiological conditions, highlighting how certain EVs, particularly exosomes, can promote or regulate infections, host immune responses, development, and various diseases -…

• UO
  University of Pittsburgh
• EC
  European Commission
• AN
  Agence Nationale de la Recherche
• FP
  Fondation pour la Recherche Médicale
• FD
  Fondation de France
• IN
  Institut National Du Cancer
• SB
  Swiss Bridge Foundation
• LI
  Labex Immuno-Oncology