articleNew England Journal of MedicineFeb 17, 2016BRONZE OA

Effects of Testosterone Treatment in Older Men

Diabetes Australia · University of Pennsylvania · +22 more institutions

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Abstract

Background

Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established.

Methods

We assigned 790 men 65 years of age or older with a serum testosterone concentration of less than 275 ng per deciliter and symptoms suggesting hypoandrogenism to receive either testosterone gel or placebo gel for 1 year. Each man participated in one or more of three trials--the Sexual Function Trial, the Physical Function Trial, and the Vitality Trial. The primary outcome of each of the individual trials was also evaluated in all participants.

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