articlemBioApr 6, 2016GOLD OA

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

MCMingliang ChenLYLong YiYZYong ZhangXZXi ZhouRLRan Li

Army Medical University

PubMed
Indexed incrossrefdoajpubmed

Abstract

UNLABELLED: The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we sought to determine whether the anti-AS effects of RSV were related to changes in the gut microbiota. We found that RSV attenuated trimethylamine-N-oxide (TMAO)-induced AS in ApoE(-/-) mice. Meanwhile, RSV decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via gut microbiota remodeling in mice. Moreover, RSV increased levels of the genera Lactobacillus and Bifidobacterium, which increased the bile salt hydrolase activity, thereby enhancing bile acid (BA)…

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751
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29.65
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100%
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Authors

9

Topics & keywords

Topics
Keywords
  • Farnesoid X receptor
  • Cholesterol 7 alpha-hydroxylase
  • Gut flora
  • Trimethylamine N-oxide
  • Enterohepatic circulation
  • Chemistry
  • Bile acid
  • Dysbiosis
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