Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells
Hefei National Center for Physical Sciences at Nanoscale · University of Science and Technology of China
Abstract
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Through the development of a drug delivery system that tethers doxorubicin onto the surface of gold nanoparticles with a poly(ethylene glycol) spacer via an acid-labile linkage (DOX-Hyd@AuNPs), we have demonstrated that multidrug resistance in cancer cells can be significantly overcome by a combination of highly efficient cellular entry and a responsive intracellular release of doxorubicin from the gold nanoparticles in acidic organelles. DOX-Hyd@AuNPs achieved enhanced drug accumulation and retention in multidrug resistant MCF-7/ADR cancer cells when it was compared with free doxorubicin. It released doxorubicin in…
Citation impact
- FWCI
- 28.23
- Percentile
- 100%
- References
- 54
Authors
6- FWFeng WangCorresponding
Hefei National Center for Physical Sciences at Nanoscale, University of Science and Technology of China
- YWYucai Wang
University of Science and Technology of China
- SDShuang Dou
University of Science and Technology of China
- MXMenghua Xiong
University of Science and Technology of China
- TSTianmeng Sun
University of Science and Technology of China, Hefei National Center for Physical Sciences at Nanoscale
Topics & keywords
- Doxorubicin
- Multiple drug resistance
- Cancer cell
- Colloidal gold
- Drug delivery
- Intracellular
- Cytotoxicity
- Endocytosis