HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

Castellsagué, Xavier; Alemany, Laia; Quer, Miquel; Halec, Gordana; Quirós, Beatriz; Tous, Sara; Clavero, Omar; Alós, Llúcia; Biegner, Thorsten; Szafarowski, Tomasz; Alejo, María; Holzinger, Dana; Cadena, Enrique; Claros, Edith; Hall, Gillian L.; Laco, Ján; Poljak, Mario; Benevolo, Maria; Kasamatsu, Elena; Mehanna, Hisham; Ndiaye, Cathy; Guimerà, Núria; Lloveras, Belén; León, Xavier; Ruiz‐Cabezas, Juan Carlos; Alvarado‐Cabrero, Isabel; Kang, C S; Oh, Jin‐Kyoung; García‐Rojo, Marcial; Iljazović, Ermina; Ajayi, Oluseyi F.; Duarte, Flora; Nessa, Ashrafun; Tinoco, Leopoldo; Durán-Padilla, Marco A.; Pirog, Edyta C.; Viarheichyk, Halina; Morales, Hesler; Costes, Valérie; Félix, Ana; Germar, Maria Julieta V.; Mena, M.; Ruacan, Arzu; Jain, Asha; Mehrotra, Ravi; Goodman, Marc T.; Lombardi, Luis Estuardo; Ferrera, Annabelle; Malami, Sani; Albanesi, Estela I.; Dabed, Pablo; Molina, Carla; López‐Revilla, Rubén; Mandys, Václav; González, Manuel; Velasco, Julio; Bravo, Ignacio G.; Quint, Wim; Pawlita, Michael; Muñóz, Núbia; Sanjosé, Silvia de; Bosch, F. Xavier

doi:10.1093/jnci/djv403

articleJNCI Journal of the National Cancer InstituteJan 28, 2016GREEN OA

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

XCXavier Castellsagué LALaia Alemany MQMiquel Quer GHGordana Halec BQBeatriz Quirós

Heidelberg University · University Hospital Heidelberg · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Background

We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable to human papillomavirus (HPV-AFs) using six HPV-related biomarkers of viral detection, transcription, and cellular transformation.

Methods

Formalin-fixed, paraffin-embedded cancer tissues of the oral cavity (OC), pharynx, and larynx were collected from pathology archives in 29 countries. All samples were subject to histopathological evaluation, DNA quality control, and HPV-DNA detection. Samples containing HPV-DNA were further subject to HPV E6*I mRNA detection and to p16(INK4a), pRb, p53, and Cyclin D1 immunohistochemistry. Final estimates of HPV-AFs were based on HPV-DNA, HPV E6*I mRNA, and/or p16(INK4a) results.

Citation impact

749

total citations

FWCI: 68.99
Percentile: 100%
References: 25

Citations per year

Authors

62

Topics & keywords

Topics

Keywords

Medicine
Head and neck
Head and neck cancer
Oncology
Internal medicine
Cancer
Surgery

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