Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO 2 Nanosheet–Aptamer Nanoprobe
Hunan University · Xiangya Hospital Central South University · +1 more institution
Abstract
A novel dual-activatable fluorescence/MRI bimodal platform is designed for tumor cell imaging by using a redoxable manganese dioxide (MnO2) nanosheet-aptamer nanoprobe. The redoxable MnO2 nanosheet acts as a DNA nanocarrier, fluorescence quencher, and intracellular glutathione (GSH)-activated MRI contrast agent. In the absence of target cells, neither fluorescence signaling nor MRI contrast of the nanoprobe is activated. In the presence of target cells, the binding of aptamers to their targets weakens the adsorption of aptamers on the MnO2 nanosheets, causing partial fluorescence recovery, illuminating the target cells, and also facilitating the endocytosis of nanoprobes into target cells. After endocytosis,…
Citation impact
- FWCI
- 20.77
- Percentile
- 100%
- References
- 37
Authors
8Topics & keywords
- Nanoprobe
- Chemistry
- Nanosheet
- Aptamer
- Fluorescence
- Fluorescence-lifetime imaging microscopy
- Nanotechnology
- Nuclear magnetic resonance