Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds
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Abstract
In recent years, carbon-hydrogen bond functionalization has evolved from an organometallic curiosity to a tool used in mainstream applications in the synthesis of complex natural products and drugs. The use of C-H bonds as a transformable functional group is advantageous because these bonds are the most abundant functionality in organic molecules. One-step conversion of these bonds to the desired functionality shortens synthetic pathways, saving reagents, solvents, and labor. Less chemical waste is generated as well, showing that this chemistry is environmentally beneficial. This Account describes the development and use of bidentate, monoanionic auxiliaries for transition-metal-catalyzed C-H bond…
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3Topics & keywords
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Keywords
- Surface modification
- Chemistry
- Amination
- Palladium
- Combinatorial chemistry
- Denticity
- Catalysis
- Carbonylation
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