Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy
University of Science and Technology of China · Georgia Institute of Technology · +3 more institutions
Abstract
A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multiple barriers by sequentially responding to the endogenous attributes of the tumor microenvironment. The smart polymeric clustered nanoparticle (iCluster) has an initial size of ∼100 nm, which is favorable for long blood circulation and high propensity of extravasation through tumor vascular fenestrations. Once iCluster accumulates at tumor sites, the intrinsic tumor extracellular acidity would…
Citation impact
- FWCI
- 53.36
- Percentile
- 100%
- References
- 48
Authors
11- HLHongjun Li
University of Science and Technology of China
- JDJin‐Zhi Du
University of Science and Technology of China, Georgia Institute of Technology, Emory University
- XDXiao‐Jiao Du
University of Science and Technology of China
- CXCong‐Fei Xu
University of Science and Technology of China, Hefei National Center for Physical Sciences at Nanoscale
- CSChun-Yang Sun
University of Science and Technology of China
Topics & keywords
- Penetration (warfare)
- Nanoparticle
- Nanotechnology
- Materials science
- Mathematics
- Good health and well-being