Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals

The current phase of drug development is witnessing an oncoming crisis due to the combined effects of increasing R&D costs, decreasing number of new drug molecules being launched, several blockbuster drugs falling off the patent cliff, and a high proportion of advanced drug candidates exhibiting poor aqueous solubility. The traditional approach of salt formulation to improve drug solubility is unsuccessful with molecules that lack ionizable functional groups, have sensitive moieties that are prone to decomposition/racemization, and/or are not sufficiently acidic/basic to enable salt formation. Several novel examples of pharmaceutical cocrystals from the past decade are reviewed, and the enhanced solubility…

• DO
  Department of Science and Technology, Ministry of Science and Technology, India
• CO
  Council of Scientific and Industrial Research, India
• EA
  Engineering and Physical Sciences Research Council

  Award: EP/G038740/1