articleScienceApr 21, 2016GREEN OA

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

LKLaura K. MackayMMMartina MinnichNANatasja A. M. KragtenYLYang LiaoBNBenjamin Nota

Australian Research Council · The University of Melbourne · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK…

Citation impact

980
total citations
FWCI
40.32
Percentile
100%
References
44
Citations per year

Authors

25

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Topics
Keywords
  • Biology
  • Medical education
  • Computer science
  • Medicine
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