DanQ: a hybrid convolutional and recurrent deep neural network for quantifying the function of DNA sequences

Modeling the properties and functions of DNA sequences is an important, but challenging task in the broad field of genomics. This task is particularly difficult for non-coding DNA, the vast majority of which is still poorly understood in terms of function. A powerful predictive model for the function of non-coding DNA can have enormous benefit for both basic science and translational research because over 98% of the human genome is non-coding and 93% of disease-associated variants lie in these regions. To address this need, we propose DanQ, a novel hybrid convolutional and bi-directional long short-term memory recurrent neural network framework for predicting non-coding function de novo from sequence. In the…

• NS
  National Science Foundation

  Awards: DGE-1321846, 1321846
• NI
  National Institutes of Health

  Awards: DGE-1321846, HG006870
• CF
  Center for Complex Biological Systems, University of California, Irvine