Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure
Shanghai Jiao Tong University · Ruijin Hospital · +2 more institutions
Abstract
Heart failure (HF) remains the most common cause of death and disability, and a major economic burden, in industrialized nations. Physiological, pharmacological, and clinical studies have demonstrated that activation of the renin-angiotensin system is a key mediator of HF progression. Angiotensin-converting enzyme 2 (ACE2), a homolog of ACE, is a monocarboxypeptidase that converts angiotensin II into angiotensin 1-7 (Ang 1-7) which, by virtue of its actions on the Mas receptor, opposes the molecular and cellular effects of angiotensin II. ACE2 is widely expressed in cardiomyocytes, cardiofibroblasts, and coronary endothelial cells. Recent preclinical translational studies confirmed a critical…
Citation impact
- FWCI
- 19.02
- Percentile
- 100%
- References
- 165
Authors
4- VBVaibhav B. PatelCorresponding
Shanghai Jiao Tong University, Ruijin Hospital, Shanghai Institute of Hypertension, Indiana University – Purdue University Indianapolis
- JZJiu-Chang Zhong
Shanghai Jiao Tong University, Ruijin Hospital, Shanghai Institute of Hypertension, Indiana University – Purdue University Indianapolis
- MBMaria B. Grant
Shanghai Jiao Tong University, Ruijin Hospital, Shanghai Institute of Hypertension, Indiana University – Purdue University Indianapolis
- GYGavin Y. Oudit
Shanghai Jiao Tong University, Ruijin Hospital, Shanghai Institute of Hypertension, Indiana University – Purdue University Indianapolis
Topics & keywords
- Renin–angiotensin system
- Angiotensin-converting enzyme 2
- Heart failure
- Angiotensin II
- Mediator
- Internal medicine
- Ejection fraction
- Angiotensin receptor
- Good health and well-being