Mesenchymal stem cells and immunomodulation: current status and future prospects
University of Hong Kong · Chinese University of Hong Kong · +3 more institutions
Abstract
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the…
Citation impact
- FWCI
- 64.55
- Percentile
- 100%
- References
- 168
Authors
9Topics & keywords
- Mesenchymal stem cell
- Immune system
- Immunology
- Stem cell
- Medicine
- Transplantation
- Induced pluripotent stem cell
- Graft-versus-host disease
- Good health and well-being