Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Speliotes, Elizabeth K.; Willer, Cristen J.; Berndt, S. I.; Monda, Keri L.; Þorleifsson, Guðmar; Jackson, Anne; Allen, Hana Lango; Lindgren, Cecilia M.; Luan, Jian; Mägi, Reedik; Randall, Joshua C.; Vedantam, Sailaja; Winkler, Thomas W.; Qi, Lu; Workalemahu, Tsegaselassie; Heid, Iris M.; Steinthórsdóttir, Valgerður; Stringham, Heather M.; Weedon, Michael N.; Wheeler, Eleanor; Wood, Abigail; Ferreira, Teresa; Weyant, Robert J.; Segrè, Ayellet V.; Estrada, Karol; Liang, Liming; Nemesh, James; Park, J. H.; Gustafsson, Stefan; Kilpeläinen, Tuomas O.; Yang, Jian; Bouatia‐Naji, Nabila; Esko, Tõnu; Feitosa, M.F.; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, André; Smith, Albert V.; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K.H.; Absher, Devin; Amin, Najaf; Dixon, Anna; Fisher, Eva; Glazer, Nicole L.; Goddard, Michael E.; Heard‐Costa, Nancy L.; Hoesel, Volker; Hottenga, Jouke‐Jan; Johansson, Åsa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, S.; Moffatt, Miriam F.; Myers, Richard H.; Narisu, N; Perry, John R. B.; Peters, Marjolein J.; Preuß, Michael; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla H.; Scott, Laura J.; Timpson, Nicholas J.; Tyrer, J. P.; Wingerden, S. van; Watanabe, Richard M.; White, Charles C.; Wiklund, Fredrik; Barlassina, Cristina; Chasman, Daniel I.; Cooper, Matthew N.; Jansson, Jan-Hakan; Lawrence, Robert; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helen; Alibrandi, Maria Teresa Sciarrone; Almgren, Peter; Arnold, Alice M.; Aspelund, Thor; Atwood, Larry D.; Balkau, Beverley; Balmforth, Anthony J.; Bennett, Amanda J.; Ben‐Shlomo, Yoav; Bergman, Richard N.; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I. F.; Boes, Tanja; Bonnycastle, Lori L.; Bornstein, Stefan R.; Brown, M. J.; Buchanan, Thomas A.; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P.; Cavalcanti-Proença, Christine; Chen, Y. D.; Chen, C. M.; Chines, Peter S.; Clarke, Robert; Coin, Lachlan; Connell, John; Day, Ian N.M.; Heijer, Martin den; Duan, Jubao; Ebrahim, Shah; Elliott, Paul; Elosúa, Roberto; Eiríksdóttir, G.; Erdos, Michael R.; Eriksson, Johan G.; Facheris, Maurizio; Felix, Stephan B.; Fischer‐Posovszky, Pamela; Folsom, Aaron R.; Friedrich, Nele; Freimer, Nelson B.; Fu, Minjie; Gaget, Stefan; Gejman, PV; Geus, Eco J. C. de; Gieger, Christian; Gjesing, Anette P.; Goel, Anuj; Goyette, Philippe; Grallert, Harald; Graessler, Juergen; Greenawalt, Danielle M.; Groves, Christopher J.; Guðnason, Vilmundur; Guiducci, Candace; Hartikainen, Anna‐Liisa; Hassanali, Neelam; Hall, Alistair S.; Havulinna, Aki S.; Hayward, Caroline; Heath, Andrew C.; Hengstenberg, Christian; Hicks, Andrew A.; Hinney, Anke; Hofman, Albert; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Iribarren, Carlos; Isomaa, Bo; Jacobs, Kevin B.; Jarick, Ivonne; Jewell, Elizabeth S.; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kaplan, Lee M.; Kathiresan, Sekar; Kettunen, JA; Kinnunen, Leena; Knowles, Joshua W.; Kolčić, Ivana; König, Inke R.; Koskinen, Seppo; Kovács, Péter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J.; Lecœur, Cécile; Lehtimäki, Terho; Lettre, Guillaume; Liu, J.; Lokki, Marja‐Liisa; Lorentzon, Mattias; Luben, Robert; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Midthjell, Kristian; Montgomery, Grant W.; Morken, Mario A.; Morris, A. P.; Mulić, Rosanda; Ngwa, Julius S.; Nelis, Mari; Neville, Matt J.; Nyholt, Dale R.; O’Donnell, Chris; O’Rahilly, Stephen; Ong, KL; Oostra, B. A.; Paré, Guillaume; Parker, Alex; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H.; Platou, Carl G. P.; Polašek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W.; Ridderstråle, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R.; Rzehak, Peter; Salomaa, Veikko; Sanders, Alan R.; Sandhu, Manjinder S.; Sanna, Serena; Saramies, J.; Savolainen, Markku J.; Scherag, Susann; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Silander, Kaisa; Sinisalo, Juha; Siscovick, David S.; Smit, Jan; Soranzo, Nicole; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J.; Tammesoo, M. L.; Tardif, Jean‐Claude; Teder‐Laving, Maris; Teslovich, Tanya M.; Thompson, John R.; Thomson, Brian; Toenjes, Anke; Tuomilehto, Jaakko; Meurs, Joyce B. 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Adrienne; Smith, George Davey; Erdmann, Jeanette; Froguel, Philippe; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B.; Hattersley, Andrew T.; Hayes, Richard B.; Heinrich, Joachim; Hu, Frank B.; Hveem, Kristian; Illig, Thomas; Järvelin, Marjo‐Riitta; Kaprio, Jaakko; Karpe, Fredrik; Khaw, Kay‐Tee; Kiemeney, L. A.; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A.; Metspalu, Andres; Munroe, Patricia B.; Ouwehand, Willem H.; Pedersen, Oluf; Penninx, Brenda W.J.H.; Peters, Annette; Pramstaller, Peter P.; Quertermous, Thomas; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Samani, N. J.; Schwarz, Peter; Shuldiner, Alan R.; Spector, T. D.; Tuomilehto, J.; Uda, Manuela; Uitterlinden, André G.; Valle, T. T.; Wabitsch, Martin; Waeber, Gérard; Wareham, Nicholas J.; Watkins, Hugh; Wilson, J. Frank; Wright, Alan F.; Zillikens, M. Carola; Chatterjee, N.; McCarroll, Steven A.; Purcell, Shaun; Schadt, E. 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doi:10.17615/d3bn-7g86

articleCarolina Digital Repository (University of North Carolina at Chapel Hill)Jan 1, 2010GREEN OA

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EKElizabeth K. Speliotes CJCristen J. Willer SIS. I. Berndt KLKeri L. Monda GÞGuðmar Þorleifsson

Broad Institute · Harvard University Press · +77 more institutions

Abstract

Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ÄÌ1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10 -8 ), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly…

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Topics & keywords

Topics

Keywords

Genetics
Body mass index
Biology
Single-nucleotide polymorphism
Obesity
SNP
Genetic association
Gene

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