Mild metal-catalyzed C–H activation: examples and concepts

Organic reactions that involve the direct functionalization of non-activated C-H bonds represent an attractive class of transformations which maximize atom- and step-economy, and simplify chemical synthesis. Due to the high stability of C-H bonds, these processes, however, have most often required harsh reaction conditions, which has drastically limited their use as tools for the synthesis of complex organic molecules. Following the increased understanding of mechanistic aspects of C-H activation gained over recent years, great strides have been taken to design and develop new protocols that proceed efficiently under mild conditions and duly benefit from improved functional group tolerance and selectivity. In…

• AV
  Alexander von Humboldt-Stiftung
• DF
  Deutsche Forschungsgemeinschaft
• L
  Leibniz-Gemeinschaft