Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature
Fudan University · Collaborative Innovation Center of Chemistry for Energy Materials
Abstract
Photothermal therapy (PTT) at present, following the temperature definition for conventional thermal therapy, usually keeps the temperature of lesions at 42-45 °C or even higher. Such high temperature kills cancer cells but also increases the damage of normal tissues near lesions through heat conduction and thus brings about more side effects and inhibits therapeutic accuracy. Here we use temperature-feedback upconversion nanoparticle combined with photothermal material for real-time monitoring of microscopic temperature in PTT. We observe that microscopic temperature of photothermal material upon illumination is high enough to kill cancer cells when the temperature of lesions is still low enough to prevent…
Citation impact
- FWCI
- 51.96
- Percentile
- 100%
- References
- 58
Authors
8Topics & keywords
- Photothermal therapy
- Materials science
- Nanotechnology
- In vivo
- Photon upconversion
- Nanoparticle
- Nanocomposite
- Biophysics