Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma
Broad Institute · Brigham and Women's Hospital · +9 more institutions
Abstract
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 incident colorectal cancers (CRCs) and integrated the results with tumor immunity, pathology, and survival data. We identified recurrently mutated genes in CRC, such as BCL9L, RBM10, CTCF, and KLF5, that were not previously appreciated in this disease. Furthermore, we investigated the genomic correlates of immune-cell infiltration and found that higher neoantigen load was positively associated with overall lymphocytic infiltration, tumor-infiltrating lymphocytes (TILs), memory T cells, and CRC-specific survival. The association with TILs was…
Citation impact
- FWCI
- 49.68
- Percentile
- 100%
- References
- 32
Authors
30- MGMarios Giannakis
Broad Institute, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute
- XJXinmeng Jasmine Mu
Broad Institute, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute
- SASachet A. Shukla
Broad Institute, Harvard University, Dana-Farber Cancer Institute
- ZRZhi Rong Qian
Harvard University, Dana-Farber Cancer Institute
- OCOfir Cohen
Broad Institute, Harvard University, Dana-Farber Cancer Institute
Topics & keywords
- Microsatellite instability
- Colorectal cancer
- Immune system
- Biology
- Tumor-infiltrating lymphocytes
- Exome sequencing
- Exome
- Cancer research
- Good health and well-being