An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Boston Children's Hospital · Humanitas University · +4 more institutions
Abstract
Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms and activate protective immunity. These cells and receptors are thought to operate in an all-or-nothing manner, existing in an immunologically active or inactive state. Here, we report that encounters with microbial products and self-encoded oxidized phospholipids (oxPAPC) induce an enhanced DC activation state, which we call "hyperactive." Hyperactive DCs induce potent adaptive immune responses and are elicited by caspase-11, an enzyme that binds oxPAPC and bacterial lipopolysaccharide (LPS). oxPAPC and LPS bind caspase-11 via distinct domains and elicit different inflammasome-dependent activities. Both lipids induce…
Citation impact
- FWCI
- 25.59
- Percentile
- 100%
- References
- 30
Authors
11- IZIvan Zanoni
Boston Children's Hospital, Humanitas University, Harvard University, University of Milano-Bicocca
- YTYunhao Tan
Boston Children's Hospital, Harvard University
- MDMarco Di Gioia
Boston Children's Hospital, Harvard University
- ABAchille Broggi
Boston Children's Hospital, Harvard University
- JRJianbin Ruan
Harvard University
Topics & keywords
- Cell biology
- Immune system
- Context (archaeology)
- Lipopolysaccharide
- Dendritic cell
- Acquired immune system
- Secretion
- Cytokine