Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. The vertebrate Nrf2 belongs to Cap 'n' Collar (Cnc) bZIP family of transcription factors and shares a high homology with SKN-1 from Caenorhabditis elegans or CncC found in Drosophila melanogaster. The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. HO-1…

• EC
  European Commission

  Awards: 02.02.00-00-014/08, POIG.02.01.00-12-064/08
• NC
  Narodowe Centrum Nauki

  Awards: 2014/14/M/NZ1/00010, 2012/07/B/NZ3/02908, 2012/06/A/NZ1/0004, 2012/07/B/NZ1/02881, 2012/06/M/NZ1/00008
• CN
  Centre National de la Recherche Scientifique
• NC
  Narodowe Centrum Badań i Rozwoju

  Award: PBS2/B7/15/2014