Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

Microglia are the only immune cells that permanently reside in the central nervous system (CNS) alongside neurons and other types of glial cells. The past decade has witnessed a revolution in our understanding of their roles during normal physiological conditions. Cutting-edge techniques revealed that these resident immune cells are critical for proper brain development, actively maintain health in the mature brain, and rapidly adapt their function to physiological or pathophysiological needs. In this review, we highlight recent studies on microglial origin (from the embryonic yolk sac) and the factors regulating their differentiation and homeostasis upon brain invasion. Elegant experiments tracking microglia…

• DF
  Deutsche Forschungsgemeinschaft
• FD
  Faculté de Médecine, Université Laval
• NS
  Natural Sciences and Engineering Research Council of Canada