Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses
Laboratoire d'Intégration des Systèmes et des Technologies · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · +2 more institutions
Abstract
Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological information is however very scarce in the literature and in metabolomics databases so far. Here we studied the influence of age, body mass index (BMI), and gender on metabolite concentrations in a large cohort of 183 adults by using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). We implemented a comprehensive statistical workflow for univariate hypothesis testing and modeling by orthogonal…
Citation impact
- FWCI
- 17.32
- Percentile
- 100%
- References
- 71
Authors
5- ETEtienne ThévenotCorresponding
Laboratoire d'Intégration des Systèmes et des Technologies, Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- ARAurélie Roux
CEA Paris-Saclay, Institut de Biologie et Technologies, Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- YXYing Xu
CEA Paris-Saclay, Institut de Biologie et Technologies, Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- ÉEÉric Ezan
Institut de Biologie et Technologies, CEA Paris-Saclay, Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- CJChristophe Junot
Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Institut de Biologie et Technologies, CEA Paris-Saclay
Topics & keywords
- Metabolome
- Metabolomics
- Univariate
- Metabolite
- Univariate analysis
- Confounding
- Urine
- OPLS