Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains

Wild, Rebekka; Gerasimaitė, Rūta; Jung, Ji‐Yul; Truffault, Vincent; Pavlovic, Igor; Schmidt, Andrea; Saiardi, Adolfo; Jessen, Henning J.; Poirier, Yves; Hothorn, Michael; Mayer, Andreas

doi:10.1126/science.aad9858

articleScienceApr 14, 2016GREEN OA

Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains

RWRebekka Wild RGRūta Gerasimaitė JJJi‐Yul Jung VTVincent Truffault IPIgor Pavlovic

University of Geneva · Jardin Botanique de Genève · +7 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Phosphorus is a macronutrient taken up by cells as inorganic phosphate (P(i)). How cells sense cellular P(i) levels is poorly characterized. Here, we report that SPX domains--which are found in eukaryotic phosphate transporters, signaling proteins, and inorganic polyphosphate polymerases--provide a basic binding surface for inositol polyphosphate signaling molecules (InsPs), the concentrations of which change in response to P(i) availability. Substitutions of critical binding surface residues impair InsP binding in vitro, inorganic polyphosphate synthesis in yeast, and P(i) transport in Arabidopsis In plants, InsPs trigger the association of SPX proteins with transcription factors to regulate P(i) starvation…

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634

total citations

FWCI: 100.35
Percentile: 100%
References: 52

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Authors

11

Topics & keywords

Topics

Keywords

Transcription factor
Inositol
Polyphosphate
Pi
Cell biology
Biochemistry
Biology
Transcription (linguistics)

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