articleScienceApr 28, 2016GREEN OA

Population-level analysis of gut microbiome variation

GFGwen FalonyMJMarie JoossensSVSara Vieira‐SilvaJWJun WangYDYoussef Darzi

VIB-KU Leuven Center for Cancer Biology · KU Leuven · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and…

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2,422
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Authors

27

Topics & keywords

Topics
Keywords
  • Gut microbiome
  • Feces
  • Microbiome
  • Gut flora
  • Population
  • Biology
  • Consistency (knowledge bases)
  • Zoology
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