Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis

Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak…

• BU
  Brown University
• UO
  University of Pittsburgh
• DC
  Dartmouth College
• SL
  South London and Maudsley NHS Foundation Trust
• NI
  National Institute for Health and Care Research
• AO
  Academy of Medical Sciences

  Award: AMS-SGCL8
• KC
  King's College London
• NU
  Newcastle University
• UO
  University of New South Wales
• UV
  Universiteit van Amsterdam
• KU
  Korea University
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: 016.156.077
• UJ
  Universitätsklinikum Jena
• UH
  Universitätsklinikum Heidelberg
• NI
  National Institutes of Health

  Awards: MH106435, R01 MH073953, P50 MH106435
• IO
  Institute of Psychiatry, Psychology and Neuroscience, King’s College London
• DO
  Department of Psychological and Brain Sciences, Dartmouth College
• MR
  Medical Research Council

  Awards: MR/J008915/1, MR/K026992/1, MR/J008915/1
• SM
  Sydney Medical School
• ID
  Instituto de Salud Carlos III

  Awards: PI14/, CP14/00041, PI14/00292
• ER
  European Regional Development Fund

  Award: PI14/00292
• NI
  National Institute of Mental Health

  Awards: R01 MH060952, MH106435, P50 MH106435, R01 MH073953, MH060952