articleNew England Journal of MedicineApr 27, 2016BRONZE OA

Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

Institut Paoli-Calmettes · Hotel Dieu Hospital · +20 more institutions

PubMed
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Abstract

Background

Ixazomib is an oral proteasome inhibitor that is currently being studied for the treatment of multiple myeloma.

Methods

In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 722 patients who had relapsed, refractory, or relapsed and refractory multiple myeloma to receive ixazomib plus lenalidomide-dexamethasone (ixazomib group) or placebo plus lenalidomide-dexamethasone (placebo group). The primary end point was progression-free survival.

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Funding